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Tumor metastasis
The CCN family of proteins of which CTGF is a member is involved
in stimulation of cell proliferation,
migration, and adhesion. Members of the CCN family, including
CTGF and Cyr61, have been implicated in cancer and causally linked
with tumor angiogenesis, invasiveness and metastasis. FibroGen has
an active research program in the discovery and development of small
molecule and protein therapeutics (see Anti-CTGF) targeting CTGF/CCN
proteins for the treatment of cancer, especially highly metastatic
cancer types, such as those that affect the bone. |
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