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Hypoxia-inducible Factor (HIF) Stabilization
Hypoxia-inducible factor (HIF) controls the body's powerful and
protective responses to hypoxia (oxygen deprivation). FibroGen is
developing small molecule inhibitors of HIF-prolyl hydroxylases
(enzymes that regulate HIF activity) to harness and direct HIF-mediated
protective mechanisms for therapeutic benefit. FibroGen's goal
is to design unique drug molecules that induce selected physiological
effects targeted to treating a particular disease or medical condition
of interest. |
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