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 | Cancer
FibroGen is working on the discovery and development of small
molecules that inhibit TGF-beta for the potential treatment of cancer.
TGF-beta is an important regulator of cell growth and is found is
abnormally high levels in certain cancers. At a certain stage of
malignancy, cells lose their ability to be growth-inhibited by TGF-beta
and produce increased amounts of TGF-beta. TGF-beta stimulates angiogenesis
(supplying the tumor with new blood vessels), suppresses the immune
system (helping the tumor escape immune defenses), and causes tumor
cells to become invasive and metastatic.
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